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Clostridium difficile Infection

Clostridium difficile, also known as C. diff, (Kloss-trid-ee-um DIFF-iss-il) is a bacterium that can be part of the normal bacteria living in the intestines and most of the time does not cause any problems.

Bacteria culture

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Fact Sheets




What causes C. difficile colitis?

If the balance of bacteria in the intestines is altered, such as in antibiotic use, C. difficile infection may develop and lead to colitis (inflammation in the colon).The colitis is caused by the production of two toxins that can lead to irritation in the colon. C. difficile can spread from person to person or through contact with objects contaminated with feces (fecal-oral transmission).

How common is C. difficile and who is at risk of developing it?

The incidence of C. difficile infections in children is on the rise. It is estimated that ~3-6% of children greater than 1 year of age may have C. difficile. These infections account for as many as 2-4 per 1000 hospital admissions for children.

The most common risk factor for C. difficile infections is antibiotic use. Other risk factors include use of antacid medications (especially proton pump inhibitors), repeated use of enemas and prolonged use of feeding tubes. Children with bowel disease such as inflammatory bowel disease and those who undergo gastrointestinal surgery are also at an increased risk for infection. Children with a weakened immune system as well as children who have been hospitalized may also develop C. difficile infection more commonly.

What are the signs and symptoms of C. difficile?

  1. Asymptomatic: some individuals may not have any symptoms. This is especially true in infants where up to 1/3 may be carriers of the bacteria. If someone has the bacteria in their intestines, they are considered to be colonized with C. difficile
  2. Diarrhea: C. difficile can cause inflammation in the colon known as colitis that may lead to diarrhea that frequently contains blood.
  3. Abdominal pain
  4. Fever
  5. Loss of appetite and weight loss

How is C. difficile diagnosed?

A C. difficile infection is suggested when a children presents with a combination of fever, abdominal pain, and bloody diarrhea. A review of the child’s current and recent medications may reveal recent use of antibiotics or long-term use of proton pump inhibitor (antacid) therapy.

A stool test is needed to confirm the diagnosis.

What tests are used in children to diagnose C. difficile?

In the presence of diarrhea, C. difficile infection is confirmed by evaluating the stool for the presence of C. difficile toxins or the genes that produce the toxins. Testing for C. difficile is not routinely done in infants less than one year of age as this group is more likely to be colonized with C. difficile without having an infection.

Sometimes a colonoscopy may be done to evaluate the diarrhea. The presence of a particular finding called pseudomembranes and an inflamed colonic mucosa (lining of the colon) suggests the diagnosis of C. difficile colitis.

What is the treatment for C. difficile infection?

In most instances, antibiotic medications are used to treat C. difficile infections. Currently, oral metronidazole is the first-line of therapy though oral vancomycin is often used. Intravenous antibiotics may be used as well for children with severe disease or who are not able to tolerate oral medications. Children also should drink plenty of fluids to avoid dehydration.

If children develop C. difficile infection while on antibiotic therapy for another illness, these medications should be stopped if possible. Use of anti-diarrheal medications such as loperamide should be avoided as well.

Fecal transplantation (stool from a donor placed in the colon of someone with C. difficile infection with a colonoscope) is currently being studied as a possible treatment for those individuals who are not responsive to routine antibiotic therapy.

What can I expect if my child has C. difficile?

The majority of children with C. difficile infections respond well to antibiotic therapy. However, as many as 30% of children may develop C. difficile again. In these instances, another course of the same antibiotic, changing to a new antibiotic, or increasing the duration of antibiotic therapy may be helpful.

Can C. difficile infection be prevented?

C. difficile can form spores, which can live a long time and can spread fecal-orally. Adequate hand washing is important to prevent the spread of the disease. Hand washing with soap and water is more effective than with alcohol hand cleaner. Proper cleaning of contaminated areas is important to prevent the spread. Since C. difficile is associated with antibiotic use, limiting the use of antibiotics may also be helpful.

In addition, breastfeeding has been shown to decrease colonization with C. difficile.

Quick Facts

  • C. difficile infection presents with fever, abdominal pain, and diarrhea (frequently with blood).
  • The incidence of C. difficile in children is estimated to be 3-6%.
  • Risk factors include hospitalization, use of antibiotics and antacid therapy and history of intestinal disorders such as inflammatory bowel disease.
  • Diagnosis is based on symptoms of diarrhea and the presence of toxins in the child’s stool.
  • Treatment is based on antibiotic therapy though there is a high recurrence rate.
  • Hand washing with soap and water is important to prevent transmission of the disease.

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IMPORTANT REMINDER: This information from the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) is intended only to provide general information and not as a definitive basis for diagnosis or treatment in any particular case. It is very important that you consult your doctor about your specific condition.

Updated November 2013